Higher beings, these worms are for you alone.

(131 worms and worm-like creatures in total so far)

(30) indie game worm bosses:
enter the gungeon - ammoconda
exit the gungeon - bolt python
risk of rain - magma worm, gilded wurms
risk of rain 2 - magma worm, overloading worm
hollow knight - gorb
haiku the robot - garbage worm
omori - king crawler, king carnivore
monolith - ice wyrm, intruder, devourer
source of madness - blood worm
terraria - eater of worlds, the destroyer
ori and the will of the wisps - giant sandworm
environmental station alpha - serpent 5
ultrakill - leviathan
mo:astray - doula, extremergy life form
the hex - the vurm
barotrauma - endworm
downwell - boss
journey - guardians
overwhelm - tunnel worm
beyond the curtain (dread x collection 5) - the meat worm
otxo - inbred basilisk
solar ash - crater ouroboros
blasphemous - scion

(53) have not played these but i was informed they had indie game worm bosses:
atomicrops - unfriendly worm
the binding of isaac - the hollow, pin, larry jr, chub, carrion queen, c.h.a.d., scolex, the frail, the shell, turdlet
noita - helvetinmato, limatoukka
wuppo - breevis
chasm - bone worm
transistor - the spine
don't starve hamlet - pugalisk
boomerang x - guardian of the heart of the scourge
cult of the lamb - leshy
rotmg - crystal worm mother, rock dragon
hades - lernean hydra
iconoclasts - starworm, the carver
titan souls - onyxia
naissance - the host
flinthook - bad billy bullseye
child of light - elemental snakes
portal knights - ancient worm, ancient evil electro worm
the void rains upon her heart - sandrome, voladrome
the walking zombie 2 - dune worm
blades of time - sand worm
brutal orchestra - keko, wringle, ouroboros
amid evil - the twin terrors
nova drift - glaucus
super meat boy - larry
anopek - bone worm
rusted moss - pestilence
patapon - zaknel, dokaknel
patapon 2 - zaknel, dokaknel
patapon 3 - zaknel, dokaknel
everblade - earthworm
birdgut - worm
islets - mega rat
rebel transmute - mutated worm
the aquatic adventures of the last human - the worm

(48) not indie but still game worm bosses:
ice worm - armored core vi: fires of rubicon
elden ring - ulcerated tree spirit
dark souls 3 - carthus sandworm
super metroid - botwoon
metroid zero mission - the acid worm
rayman origins - giant eel, murray
genshin impact - ruin serpent
metroid - serris
half life - pit worm
splatoon 2 and 3 - steel eel
zelda: a link to the past - moldorm, lanmolas
zelda: twilight princess - twilit aquatic morpheel
zelda: wind waker - molgera
zelda: skyward sword - bilocyte
zelda: ocarina of time - volvagia
earthbound - kraken
shadow of the colossus - 7th, 10th and 13th colossi
mario odyssey - mecha wiggler
resident evil - gulp worm
sonic boom: rise of lyric - driller worm
sonic adventure 1/dx - perfect chaos
sonic 06 - iblis worm
sonic chronicles: the dark brotherhood - colossal worm
sonic lost world - unnamed(?) pink worm, the sand worm
sonic frontiers - titan wyvern
sonic mania - unnamed(?) pink worm
super mario 64 - wiggler
super mario sunshine - wiggler
mario & luigi: superstar saga - wiggler
super princess peach - wiggler
mario kart ds - wiggler
mario & luigi: partners in time - swiggler
mario & luigi: bowser's inside story - wiggler
mario party 9 - wiggler
mario & luigi: dream team - wiggler and popple
mario & luigi: paper jam - wiggler and kamek
mario & luigi: superstar saga + bowser's minions - wiggler
panzer dragoon - sand worm
magical quest starring mickey mouse - fat worm
ff2 - roundworm
ff4 - gigas worm
ff5 - sandworm
ff9 - Ralvurahva

inform me of worm bosses i have missed
(no i am NOT adding calamity mod, it's a mod not a game)

next thing i'm adding is a separate section for the worm-likes since people keep telling me "umm actually this one isn't a worm"