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Development began in April 2009, two months before The Hangover was released. The principal actors were cast in March 2010 to reprise their roles from the first film. Production began in October 2010, in Ontario, California, before moving on location in Thailand. The film was released on May 26, 2011, and became the eighth-highest-grossing film of 2011 and the highest-grossing R-rated comedy during its theatrical run, but unlike the first film, The Hangover Part II received mixed reviews.
The causes of IBS may well be multi-factorial.[2] Theories include combinations of "gut–brain axis" problems, alterations in gut motility, visceral hypersensitivity, infections including small intestinal bacterial overgrowth, neurotransmitters, genetic factors, and food sensitivity.[2] Onset may be triggered by an intestinal infection[11] ("post-infectious irritable bowel syndrome") or a stressful life event.[12]