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It is not worth using them on anything else before those two. After that, the best choices are either the two Estus Shards or Fang Key (Ornifex)/Straid/Vengarl's Body, depending on which one sounds most appealing.
Then there's the one statue guarding some Effigies in Shaded Woods. The one guarding the Sublime Bone Dust is bypassable, you can do a very easy jump to reach the chest no problem. In the OG, one of the Estus Shards was also next to Ornifex instead of a DIFFERENT Yore statue location.
In Scholar, you can get 4/5 of the Sublime Bone Dust long before getting near one of the Great Ones, however the last one is in Drangleic Castle, far later than any of them in the OG.
Technically, Straid of Olaphis also requires 3/3 INT/FTH to speak to, however this requirement functionally doesn't exist because no class has either stat at that low of a level.