Hello and welcome to my Guide for the Death Campaign on Lethal Difficulty! In the following paragraphs I will go through each of the missions and give tips and a general strategy to go by so you can beat the Death Campaign.

I will outlay a general strategy for this game in the description to the first mission and from then on, only go into what you need to adjust in the following missions as the general strategy we use in the first mission will be applicable to most other missions.

Another thing up front: always check the Ressource Upgrade options early on to know what to go for, they are important. Always.

A video for each mission will be included, if you however do not feel like reading through the whole thing, a playlist with all the missions will be here: Bio Inc. Redemption Death Campaign: Lethal Difficulty

The first mission of the game will be "Head Start" in the "Morgue" Stage. The first step is to pick the skills you want to pick for your mission. When starting a new game, you will only be able to pick a single skill. I will however expand on what other skills I find important and in case you already played more, you can pick more skills aswell.
I would therefor start with the skill called "Collateral Damage" in the Diseases tree.
Reason being is that it improves your performance across the board and we often want to go for diseases that affect several systems.

The 2nd most important skill to pick, in my opinion, will be "Overweight" for our particular strategy. This one can be found in the Risk Factors tree.
Reason for this is that for the first mission, we will go for a weight based strategy and the weight based Risk Factors are very strong in general.

The 3rd skill I'd pick is from the Recovery tree and we will go for "Poor Treatments" so that treated diseases still have an effect as all treatments lose some effectiveness and time really isn't much of a concern.

The 4th skill we go for in this case is "Better Ressources" from the Economy tree. Once again, we don't need to worry about speed in this one so getting higher value points throughout the game benefits us the most.

The 5th skill picked will be "Quick Collapse" from the Environment tree as all other skills in this tree don't offer much help or advantage to beating the mission.

Now after we are done picking our skills, we start the game by collecting Bio Points and evolving Risk Factors. In the mission "Head Start" we already start with 4 Risk Factors but since we picked "Overweight" earlier, we will evolve more weight related Risk Factors. Therefor the overall strategy will be to fully purchase all Risk Factors form the middle tree.

Picking up additional Risk Factors can be done but is not required at that stage. You can also pick up some things from the Recovery tab in order to delay him going to the doctor or making the doctors slower.

Our next step is attacking the Circulatory system heavily as most of the weight related Risk Factors improve the diseases from that tree.
We also want to attack the Immune system because for the first Ressource Upgrade, we need to take down the Immune System to 80% health.

Once we have taken down the Circulatory System, every other system will start taking light damage. Now you are free to attack whichever system you feel like, judging from where you have the most Risk Factor buffs and which ones are pretty far down already. The more systems you kill the faster the other systems will take more damage.

Two more things to keep in mind:
While a disease is being cured, you should quickly pick up the following disease in the tree or else it is locked. That way you can take your time and play the doctor a bit.
When severe diseases are being treated, buying time through going for the Strike ability in the Recovery tab can get you an important amount of extra damage by keeping the disease going for a bit longer.

Now you should be in prime position to beat the first mission as it is really not that difficult. Most of the principles used in this one will be applicable to other missions aswell so from now on, I will only go into changes and how the strategy needs to be altered to beat other missions.

The 2nd mission of the game "Death Race" is still in the "Morgue" Stage and now we have to beat an AI opponent and kill our patient quicker.

The skills I picked are:
1. "Collateral Damage" from the Disease Tree
2. "Risks Boost" from the Risk Factor Tree
3. "Quick Collapse" from the Environment Tree
4. "Better Ressources" from the Economy Tree
5. Whatever you feel like from the Recovery Tree because there is no doctors in this mission

Once again we start off by evolving Risk Factors, which improves our killing performance later on. Don't be concerned by the AI starting to weaken him earlier. Having the Risk Factors ready will allow you to quickly overtake the AI.

This time, I decided to go into the "Drug Addict" Risk Factor which is the last one of the bottom right tree. That allows you to go into the Nervous system early. You should also pick up quite a few of the low cost diseases to boost you overall performance.

The main disease I want to go for in this one is the "Major Depression" to make full use the "Collateral Damage" skill we picked earlier as Major Depression affects every single system.

From that point on, you want to look at which systems have the most Risk Factors working against it and slowly gathering up points and targeting those systems. Once again you want to quickly take down 1 or 2 of them to accelerate the process as killed systems deal extra damage to all systems.

Now you will easily overtake the AI as you built up enough Risk Factors to enhance your performance enough.

The third mission called "Young and Healthy" is the last mission of the "Morgue" Stage.

The Skills I went for are:

1. "Collateral Damage" from the Diseases Tree
2. "Risks Boost" from the Risk Factors Tree
3. "Poor Treatments" from the Recovery Tree
4. "Quick Collapse" from the Environment Tree
5. "Better Ressources" from the Economy Tree

Important to note is that you don't want to pick a weight based skill choice or gameplay. This person is young and healthy so some Risk Factors are not available, including the weight based and age based ones.

Therefor, Risk Factors are not as much of a priority as in other missions, however you still want to grab all of the available ones, it is really not that many. Keep in mind that you have all the time in the world as he is young and healthy and doesn't have any need to go to the doctor. Therefor you can set up your strategy to your liking.

Delaying his visit to the doctor through the skills in the Recovery tree makes sense in this one as you don't spend too many of your points on Risk Factors.
Same goes for making the doctors slower before any of the Recovery is starting.

Once you are set with your strategy, you want to build up a decent stockpile of Bio Points (around 20 or more) and then start attacking him quite hard at once. When picking all the available Risk Factors, going for the Renal System early makes sense as it is one of only two systems that has 2 Risk Factors working for it.

Now it works as always, attack the weakened systems, take down one at a time to improve overall damage done and try to go for the systems first that have most Risk Factors on it or are already low. Now you should not have any trouble beating the mission.

The 4th mission overall "Total Failure" is also the first mission of the Graveyard Stage.

In this mission we need to terminate all the systems as opposed to only try to get him down to 0% health.

The Skills we pick are as follows:

1. "Overweight" in the Risk Factors Tree
2. "Collateral Damage" in the Disease Tree
3. "Poor Treatments" in the Recovery Tree
4. "Quick Collapse" in the Environment Tree
5. " Better Ressources" in the Economy Tree

This one is once again straight forward, first we go for the weight related Risk Factors. Then it's up to you how many additional Risk Factors you want to pick, the bottom right one is probably your best choice. Especially Workaholic as that reduces the cost for the nervous system diseases by 2.

As we went for the weight related Risk Factors, going for the Circulatory system first makes a lot of sense. Once that is targeted and goes down, all other systems take damage. As in every other mission, look for the systems that are close to death and have most Risk Factors working on them and target those most.

The Recovery options are in most cases not needed, you can however make the doctors slower and that helps out a little bit. However, the strength you have thanks to the Risk Factors allows you to quickly terminate one system after the other.

Waiting for him to go to the doctor and until then, evolving Risk Factors and stacking up points is a decent timing strategy and allows you to maximize your build as time concerns are not there in this mission.

The 5th overall mission and 2nd mission of the Graveyard stage is called "Cardiorespiratory Arrest".

The skills I picked for this mission are as follows:

1. "Random Risks" from the Risk Factors Tree
2. "Poor Treatments" from the Recovery Tree
3. "Collateral Damage" from the Diseases Tree
4. Quick Collapse" from the Environment Tree
5. "Better Ressources" from the Economy Tree

The part that changes in this mission is that he is already at the doctor and has the Recovery started. Therefor we do not have time to evolve tons of Risk Factors first, therefor I want the two random ones from the start. He does however already start with two of them and those can overlap so while you would expect four of them, there is a chance you only get two or 3 in total and wasted the skill. Keep that in mind when making that decision.

As you need to act quickly in this one, you want to quickly go into Diseases. My personal choice is going into the "Stroke" which helps defeating the Cicrulatory system and also immediatly attacks the Nervous system.

Then, look for a third system that has taken damage or has Risk Factors and spread out your diseases in order to take down three of them quickly.

As you progress, you will notice that their Recovery progress jumps up quickly. Should you ever come into a difficult situation where the Recovery progress gets too high, there are options in the Recovery tree to reset some of that progress. Putting them on strike to buy your diseases more time is also a very valid choice.

As long as you always target the weakened systems and use that to accelerate your overall progress, you won't have much trouble killing the patient quickly. Keeping an eye out on the Recovery is advised but if played properly, none of the delaying tactics are needed.

The 6th mission "Time Bomb" is the 3rd and last mission of the Graveyard stage.

The skills I picked are as follows:

1. "Collateral Damage" from the Diseases Tree
2. "Overweight" from the Risk Factors Tree
3. "Slow Diagnosis" from the Recovery Tree
4. "Quick Collapse" from the Environment Tree
5. "Better Ressources" from the Economy Tree

The notable change from this mission is that you only have 10 minutes to kill the patient. Keep in mind here that the time keeps ticking while you are in the Bio Map so you should always know what you want to go for.

The first step is again to go for the Risk Factors. Pick up a few of the weight related Risk Factors but keep in mind that the available time is really short.
Therefor, you only want to go into the weight based Risk Factor tree, which is the middle one. I would also suggest to only go for the 4 basic ones and skip out on the last weight based Risk Factor.

That means you should go into Diseases somewhere around the 8 minute mark. Then we go into the Circulatory system as we have now 4 Risk Factors affecting it and want to take it down quickly.

A valid strategy is to go either into the Stroke or the Pulmonary Embolism on the Circulatory system Diseases because those heavily affect another system aswell. Depending on your choice, you now want to go into the second system (whichever was affected by your previous choice) and then heavily target down the second system.

Once you quickly get down one or two systems, the snowball effect will allow you kill him with ease in the remaining time. For reference, you should at least be down to 75% at the 4:30 minute mark. At that point it should slowly start to snowball and quickly take down his health.

You should also strongly consider putting the doctors on strike whenever they are trying to cure one of your top tier diseases as that allows more damage being done quickly.

the 7th mission of the game "Perfect Lifestyle" is also the 1st mission of the Slaughterhouse stage.

The skills I picked are as follows:

1. "Risks Boost" from the Risk Factors Tree
2. "Collateral Damage" from the Diseases Tree
3. "Poor Treatments" from the Recovery Tree
4. "Quick Collapse" from the Environment Tree
5. "Better Ressources" from the Economy Tree

For the most part, this mission is very similar to the rest and therefor we go for Risk Factors early and hard. Go for as many as you like, you have all the time in the world in this mission.
In a way, grabbing Risk Factors is even more important than ever just because the doctors now use more Lifestyles, which basically counteracts the Risk Factors as it boosts the systems.

So you at least want to counteract the Lifestyles with the Risk Factors. Then you want to look at the systems and look for one where you have more Risk Factors going than he has Lifestyles. That gives you an advantage and it should be used wisely. Gather up a few points and heavily attack the first system of choice. Once you are getting that first system low, quickly move onto other systems and try to simply ignore the ones where plenty of Lifestyles are working against you.

This mission is really about adapting to where he has most Lifestyles and where your biggest advantages are in place. Overall it is however still one of the easier missions as you have as much time as you want to take to set up your strategy.

The 8th mission "Deadline" is also the 2nd mission of the Slaughterhouse stage.

The skills I chose are as follows:

1. "Risks Boost" from the Risk Factors Tree
2. "Collateral Damage" from the Diseases Tree
3. "Slow Treatments" from the Recovery Tree
4. "Quick Collapse" from the Environment Tree
5. "Better Ressources" from the Economy Tree

For this mission, you have 300 days to kill the patient. This is actually easier than the 10 minute challenge and therefor a similar but more open strategy will be used.

We once again start with Risk Factors and this time I want to go into the bottom right tree in oder to attack the Nervous system first.
Once we are up to Drug Addict it is really up to you where you want to take it, a few extra Risk Factors are useful but not required. The time to do it is certainly available.

With somewhere between 200 and 250 days remaining you want to start going heavily into diseases. In my case, going into the Nervous system certainly was the best idea, depending on which Risk Factors you picked up, other systems are a good possibilty aswell.

From that point on, it is a very straightforward mission, take down one system quickly, work on other ones with Risk Factors and then strategically focus them down.

The 9th and final mission of both the Death Campaign and the Slaughterhouse stage is called "Road Block".

The skills I picked are as follows:

1. "Risks Boost" from the Risk Factors Tree
2. "Collateral Damage" from the Diseases Tree
3. "Slow Diagnosis" from the Recovery Tree
4. "Better Ressources" from the Economy Tree
5. "Quick Collapse" from the Environment Tree

One thing the game does not tell you up front is that you have to terminate all the systems in this mission aswell. You do need to keep in mind that the doctors will cure quickly, that is why we don't him to actually go to the doctor quickly.

Therefor, we once again go into Risk Factors early, I suggest spreading out the Risk Factors to have at least one Risk Factor for every system as you need to terminate all of them.

For this mission, I also suggest going for some of the Recovery options to delay the doctors and counteract their strength in this mission.

The main gameplay strategy from now on is the same as in all other missions, focus down the first system, then go into wherever you find weaknesses and from that point on, snowball it thanks to the additional damage from killed systems.

The main difference is to always pay attention to where they are treating the ressources. You want to try to avoid them cutting off paths early, so when a disease is being treated, you want to make sure you pick up the next one down the path until the specific system is down.

And this is it. The entire Death Campaign on Lethal Difficulty. It is certainly the easier and more straightforward Campaign of the two but still has its tricky moments here or there. However, the missions really don't differ too much and allow you to go for very similar strategies throughout.

I hope this guide helps you out with whichever missions you had trouble with and I hope you can now also beat all the Death Campaign missions.

If you have any questions or suggestions on how to improve the guide, feel free to leave feedback.